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KFSP Tumor Oxygenation


The following publications by members of the KFSP Tumor Oxygenation have been published between 2012 and 2016 and are related to the topic of tumor hypoxia and tumor oxygenation.


Ahnen L., Wolf M., Hagmann C., Sanchez S. Near-Infrared Image Reconstruction of Newborns' Brains: Robustness to Perturbations of the Source/Detector Location. Adv Exp Med Biol., 2016, 876, 377-382.

Gutsche K., Randi E., Blank V., Fink D. Wenger R., Leo C., Scholz C. Intermittent Hypoxia Confers Pro-metastatic Gene Expression Selectively Through NF-κB in Inflammatory Breast Cancer Cells Free Radical Biology and Medicine, 101, 2016, 129-142.

Nasseri N., Kleiser S., Reidt S., Wolf M. Local Measurement of Flap Oxygen Saturation: An Application of Visible Light Spectroscopy. Adv Exp Med Biol. 2016, 876, 391-397.

Kleiser S., Nasseri N., Andresen B., Greisen G., Wolf M. Comparison of Tissue Oximeters on a Liquid Phantom with Adjustable Optical Properties. Biomedical Optics Express, 2016, 7(8), 2973-2992.

Fuady J.H, Gutsche K., Santambragio S., Varga Z., Hoogewijs D., Wenger R.H.Estrogen-Dependent Downregulation of Hypoxia-Inducible Factor (HIF)-2a in Invasive Breast Cancer Cells Oncotarget, 2016, 7(21), 31153-31165.


Ahnen L., Wolf M., Hagmann C., Sanchez S. Near-Infrared Image Reconstruction of Newborns’ Brains: Robustness to Perturbations of the Source/Detector Location Advances in Experimental Medicine and Biology, in press.

Broggini-Tenzer A., Sharma A., Nytko K., Vuong V., Orlowski K., Hug D., O’Reilly T., Pruschy M. Combined Treatment Strategies for Microtubule Stabilizing Agent-Resistant Tumors Journal of National Cancer Institute, 2015, 107(4).

Gotzamanis G., Kocian R., Oezbay P., Redle R., Spyridon K., Eberhardt C., Boss A., Nanz D., Rossi C. In Vivo Quantification of Cerebral R2*-Response to Graded Hyperoxia at 3 Tesla Journal of Clinical Imaging Science, 2015, 5(1), 1-8.

Lelli A., Nolan K.A., Santambrogio S., Goncalves A.F., Schönenberger M.J., Guinot A., Frew I.J., Marti H.H., Hoogewijs D., Wenger R.H. Induction of Long Noncoding RNA MALATI in Hypoxic Mice Hypoxia, 2015, 3, 45-52.

Luecker A., Weber B., Jenny P. A Dynamic Model of Oxygen Transport from Capillaries to Tissue with Moving Red Blood Cells American Journal of Physiology - Heart and Circulatory Physiology, 2015, 308(3), 206-216.

Mata Pavia J., Scandini M., Lindner S., Wolf M., Charbon E. A 400x4 Backside-Illuminated SPAD Image Sensor with 49.7 ps Resolution, 30 pJ/Sample TDCs Fabricated in 3D CMOS Technology for Near-Infrared Optical Tomography IEEE Journal of Solid-State Circuits, 2015, 15(10), 2406-2418.

Müller-Edenborn K., Léger K., Glaus Garzon J.F., Oertli C., Mirsaidi A., Richards P.J., Rehrauer H., Spielmann P., Hoogewijs D., Borsig L., Hottiger M.O., Wenger R.H. Hypoxia Attenuates the Proinflammatory Response in Colon Cancer Cells by Regulating IκB Oncotarget, 2015, 6(24), 20288-20301.

Nesteruk M., Lang S., Veit-Haibach P., Studer G., Stieb S., Glatz S., Hemmatazad H., Ikenberg K., Huber G., Pruschy M., Guckenberger M., Klöck S., Riesterer O., Tumor Stage, Tumor Site and HPV Dependent Correlation of Perfusion CT Parameters and [18F]-FDG Uptake in Head and Neck Squamous Cell Carcinoma Radiotherapy and Oncology, 2015, 117(1), 125-131.

O'Connor T., Borsig L., Heikenwalder M. CCL2-CCR2 Signaling in Disease Pathogenesis Endocrine, Metabolic and Immune Disorders - Drug Targets, 2015, 15(2), 105-118.

Pruschy M. The Radiobiological Aspects of Tumor Hypoxia, in Recent Results in Cancer Research, invited book chapter to be published in 2015.

Schörg A., Santambrogio S., Platt J.L., Schödel J., Lindenmeyer M.T., Cohen C.D., Schrödter K., Mole D.R., Wenger R.H., Hoogewijs D. Destruction of a Distal Hypoxia Response Element Abolishes Trans-activation of the PAG1 Gene Mediated by HIF-independent Chromatin LoopingNucleic Acids Research, 2015, 43(12), 5810-5823.

Stieb S., Lang S., Linsenmeier C., Graydon S., Riesterer O. Safety of High-Dose-Rate Stereotactic Body Radiotherapy Radiation Oncology, 2015, 10(27).

Vital D., Morand G., Huber G.F., Studer G., Holzmann D. Outcome in Squamous Cell Carcinoma of the Nasal Vestibule: A Single Center Experience Head & Neck, 2015, 37(1), 46-51.

Wenger R.H., Kurtcuoglu V., Scholz C.C., Marti H.H., Hoogewijs D. Frequently Asked Questions in Hypoxia Research Hypoxia, 2015, 3, 35-43.


Borsig L., Wolf M.J., Roblek M., Lorentzen A., Heikenwalder M. Inflammatory Chemokines and Metastasis – Tracing the Accessory Oncogene, 2014, 33(25), 3217-3224.

Buergi S., Seuwen A., Keist R., von Berg J., Rudin M. In Vivo Imaging of HIF Regulation in Subcutaneous and Orthotopic GL261 Glioma Tumor Model Using a Reporter Gene Assay Molecular Imaging, 2014, 13, doi: 10.2310/7290.2014.00029.

Fuady J.H., Bordoli M.R., Abreu-Rodríguez I., Kristiansen G., Hoogewijs D., Stiehl D.P., Wenger R.H. HIF Mediated Induction of WISP-2 Contributes to Attenuated Breast Cancer Progression Hypoxia, 2014, 2, 23-33.

Gander T., Studer S., Studer G., Grätz K.W., Bredell M. Medium-Term Outcome of Astra Tech Implants in Head and Neck Oncology Patients International Journal of Oral and Maxillofacial Surgery, 2014, 43(11), 1381-1385.

Goetti R., Warnock G., Kuhn F.P., Guggenberger R., O'Gorman R., Buck A., Khan N., Scheer I. Quantitative Cerebral Perfusion Imaging in Children and Young Adults with Moyamoya Disease: Comparison of Arterial Spin-Labeling-MRI and H(2)[(15)O]-PET American Journal of Neuroradiology, 2014, 35(5), 1022-1028.

Häuselmann I., Borsig L. Altered Tumor Cell Glycosylation Promotes Metastasis Frontiers in Oncology, 2014, 4(28), 1-15.

Helbig L., Koi L., Brüchner K., Gurtner K., Hess-Stumpp H., Unterschemmann K., Pruschy M., Baumann M., Yaromina A., Zips D. Hypoxia-Inducible Factor Pathway Inhibition Resolves Tumor Hypoxia and Improves Local Tumor Control after Single-Dose Irradiation International Journal of Radiation Oncology Biology Physics, 2014, 88(1), 159-166.

Hoos A., Protsyuk D., Borsig L. Metastatic Growth Progression Caused by PSGL-1-Mediated Recruitment of Monocytes to Metastatic Sites Cancer Research, 2014, 74(3), 695-704.

Hu H.Y., Vats D., Vizovisek M., Kramer L., Germanier C., Wendt K.U., Rudin M. , Turk B., Plettenburg O., Schultz C. In Vivo Imaging of Mouse Tumors by a Lipidated Cathepsin S Substrate Angewandte Chemie-International Edition, 2014, 53(29), 7669-7673.

Janssen S., Glanzmann C., Huber G., Studer G. Risk-Adapted Partial Larynx and/or Carotid Artery Sparing Modulated Radiation Therapy of Glottic Cancer Radiation Oncology, 2014, 9, 136.

Janssen S., Glanzmann C., Huber G., Studer G. Individualized IMRT Treatment Approach for Cervical Lymph Node Metastases of Unknown Primary Strahlentherapie und Onkologie, 2014, 190(4), 386-393.

Kuhn F.P., Warnock G.I., Burger C., Ledermann K., Martin-Soelch C., Buck A. Comparison of PET Template-Based and MRI-Based Image Processing in the Quantitative Analysis of C11-Raclopride PET European Journal of Nuclear Medicine and Molecular Imaging Research, 2014, 4(1), 7.

Lang S., Zeimetz J., Ochsner G., Schmid Daners M., Riesterer O., Klöck S. Development and Evaluation of a Prototype Tracking System Using the Treatment Couch Medical Physics, 2014, 41(2), 021720.

Lanzer M., Gander T., Lübbers H.T., Metzler P., Bredell M., Reinisch S. Preservation of Ipsilateral Submandibular Gland Is Ill Advised in Cancer of the Floor of the Mouth or Tongue Laryngoscope, 2014, 124(9), 2070-2074.

Lohri C., Hutzli Schaltegger C.S., van den Broek M., Wenger R.H., Ruegg C., Fink D., Fehr M.K., Knuth A., Zweifel M. Neutrophil Expression of ICAM1, CXCR1, and VEGFR1 in Patients with Breast Cancer Before and After Adjuvant Chemotherapy Anticancer Research, 2014, 34, 4693-4699.

Mariani C.J., Vasanthakumar A., Madzo J., Yesilkanal A., Bhagat T., Yu Y., Bhattacharyya S., Wenger R.H., Cohn S.L., Nanduri J., Verma A., Prabhakar N.R., Godley L.A. TET1-Mediated Hydroxymethylation Facilitates Hypoxic Gene Induction in Neuroblastoma Cell Reports, 2014, 7, 1343-1352.

Mata Pavia J., Wolf M., Charbon E. Measurement and Modeling of Microlenses Fabricated on Single-Photon Avalanche Diode Arrays for Fill Factor Recovery Optical Express, 2014, 22(4), 4202-4213.

Mata Pavia J., Wolf M., Charbon E. Single-photon Avalanche Diode Images Applied to Near-infrared Imaging IEEE Journal of Selected Topics in Quantum Electronics, 2014, 20(6).

Meller S., Bicker A., Montani M., Ikenberg K., Rostamzadeh B., Sailer V., Wild P., Dietrich D., Uhl B., Sulser T., Moch H., Gorr T.A., Stephan C., Jung K., Hankeln T., Kristiansen G. Myoglobin Expression in Prostate Cancer Is Correlated to Androgen Receptor Expression and Markers of Tumor Hypoxia. Virchows Archiv: An International Journal of Pathology, 2014, 465(4), 419-427.

Quandt B.M., Scherer L.J., Boesel L.F., Wolf M., Bona G.L., Rossi R.M. Body-Monitoring and Health Supervision by Means of Optical Fiber-Based Sensing Systems in Medical Textiles, Advanced Healthcare Materials, 2014, 4(3), 330-355.

Reinisch S., Kruse A., Bredell M., Lübbers H.T., Gander T., Lanzer M. Is Lymph-Node Ratio a Superior Predictor than Lymph Node Status for Recurrence-Free and Overall Survival in Patients with Head and Neck Squamous Cell Carcinoma? Annals of Surgical Oncology, 2014, 21(6), 1912-1918.

Scholkmann F., Metz A., Wolf M. Measuring Tissue Hemodynamics and Oxygenation by Continuous-Wave Functional Near-Infrared Spectroscopy – How Robust Are the Different Calculation Methods against Movement Artifacts? Physiological Measurement, 2014, 35(4), 717–734.

Shen C.J., Sharma A., Vuong D.-V., Erler J.T., Pruschy M., Broggini-Tenzer A. Ionizing Radiation Induces Tumor Cell Lysyl Oxidase Secretion BMC Cancer, 2014, 14, 532.

Storti F., Santambrogio S., Crowther L., Otto T., Abreu-Rodríguez I., Kaufmann M., Hu C.-J., Dame C., Fandrey J., Wenger R.H., Hoogewijs D. A Novel Distal Upstream Hypoxia Response Element Regulating Oxygen-Dependent Erythropoietin Gene Expression Haematologica, 2014, 99(4), e45-e48.


Broglie M.A., Soltermann A., Rohrbach D., Haile S.R., Pawlita M., Studer G., Huber G.F., Moch H., Stoeckli S.J. Impact of p16, p53, Smoking, and Alcohol on Survival in Patients with Oropharyngeal Squamous Cell Carcinoma Treated with Primary Intensity-Modulated Chemoradiation Head & Neck, 2013, 35(12), 1698-1706.

Dominietto M., Lehmann S., Keist R., Rudin M. Magnetic Resonance Imaging and Pattern Analysis in the Study of Tumor Angiogenesis Magnetic Resonance in Medicine, 2013, 70(5), 1481-1490.

Furmanova P., Eggel M., Millard A.-L., Pruschy M. The Microtubule Stabilizer Patupilone Counteracts Ionizing Radiation-Induced Matrix Metalloproteinase Activity and Tumor Cell Invasion Radiation Oncology, 2013, 8, 105.

Kaufmann M.R., Barth S., Konietzko U., Wu B., Egger S., Kunze R., Marti H.H., Hick M., Müller U., Camenisch G., Wenger R.H. Dysregulation of Hypoxia-Inducible Factor by Presenilin/y-Secretase Loss-of-Function Mutations Journal of Neuroscience, 2013, 33, 1915-1926.

Kaufmann M.R., Schraml P., Hermanns T., Wenger R.H., Camenisch G. Onconeuronal Antigen Cdr2 Correlates with HIF Prolyl-4-Hydroxylase PHD1 and Worse Prognosis in Renal Cell Carcinoma Experimental Molecular Pathology, 2013, 94, 453-457.

Perrotta S., Stiehl D.P., Punzo F., Scianguetta S., Borriello A., Bencivenga D., Casale M., Nobili B., Fasoli S., Balduzzi A., Cro L., Nytko K.J., Wenger R.H., Della Ragione F. Congenital Erythrocytosis Associated with Gain-of-Function HIF2A Gene Mutations and Erythropoietin Levels in the Normal Range Haematologica, 2013, 98, 1624-1632.

Regan Anderson T.M., Peacock D.L., Daniel A.R., Hubbard G.K., Lofgren K.A., Girard B.J., Schörg A., Hoogewijs D., Wenger R.H., Seagroves T.N., Lange C.A. Breast Tumor Kinase (Brk/PTK6) Is a Mediator of Hypoxia/HIF-Associated Breast Cancer Progression Cancer Research, 2013, 73, 5810-5820.

Rohrer Bley C., Furmanova P., Orlowski K. , Grosse N., Broggini-Tenzer A., McSheehy P. MJ., Pruschy M. Microtubule Stabilizing Agents and Ionizing Radiation: Multiple Exploitable Mechanisms for Combined Treatment European Journal of Cancer, 2013, 49(1), 245-253.

Stephanie L., Shrestha B., Graydon S.N., Cavelaars F., Linsenmeier C., Klöck S., Studer G., Riesterer O. Clinical Application of Flattening Filter Free Beams for Extracranial Stereotactic Radiotherapy Radiotherapy and Oncology, 2013, 106(2), 255-259.

Studer G., Glanzmann C. Volumetric Stratification of cT4 Stage Head and Neck Cancer Strahlentherapie und Onkologie, 2013, 189(10), 867-873.

Studer G., Glanzmann C. Volumetric Staging in Oropharyngeal Cancer Patients Treated with Definitive IMRT Oral Oncology, 2013, 49(3), 269-276.

Studer G., Linsenmeier C., Riesterer O., Najafi Y., Brown M., Yousefi B., Bredell M., Huber G., Schmid S., Studer S., Zwahlen R., Rordorf T., Glanzmann C. Late Term Tolerance in Head Neck Cancer Patients Irradiated in the IMRT Era Radiation Oncology, 2013, 8(1), 259.

Veit-Haibach P., Schmid D., Strobel K., Soyka J.D., Schaefer N.G., Haerle S.K., Huber G., Studer G., Seifert B., Hany T.F. Combined PET/CT-Perfusion in Patients with Head and Neck Cancers European Radiology, 2013, 23(1), 163-173.

Wrann S., Kaufmann M.R., Wirthner R., Stiehl D.P., Wenger R.H. HIF Mediated and DNA Damage Independent Histone H2AX Phosphorylation in Chronic Hypoxia Biological Chemistry, 2013, 394(4), 519-528.

Zimmermann R., Braun F., Achtnich T., Lambercy O., Gassert R., Wolf M. Silicon Photomultipliers for Improved Detection of Low Light Levels in Miniature Near-Infrared Spectroscopy Instruments Biomedical Optics Express, 2013, 4(5), 659-666.


Orlowski K., Rohrer Bley C., Zimmermann M., Vuong V., Hug D., et al. Dynamics of Tumor Hypoxia in Response to Patupilone and Ionizing Radiation PLoS ONE, 2012, 7(12), e51476.